KEGG T01001: 2555

Homo sapiens (human): 2555

Entry

2555              CDS       T01001

Symbol

GABRA2, DEE78, EIEE78

Name

(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha2

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H00606

Early infantile epileptic encephalopathy

H01611

Alcohol dependence

Drug target

Abecarnil:

D02594

Adinazolam (DG00911):

D02770 D02771

Adipiplon:

D08840

Alpidem:

D02833

Alprazolam:

D00225<JP/US>

Aminobutyric acid:

D00058<JP>

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

D11149<US>

Bromazepam:

D01245<JP>

Brotizolam:

D01744<JP>

Butabarbital (DG01308):

D00699 D03180

Butobarbital:

D02618

Cenobamate:

D11150<US>

Chlordiazepoxide (DG00908):

D00267<JP> D00693<US>

Cinolazepam:

D07328

Cipepofol:

D12449

Clobazam:

D01253<JP/US>

Clonazepam:

D00280<JP/US>

Clotiazepam:

D01328<JP>

Cloxazolam:

D01268<JP>

Darigabat:

D12146

Delorazepam:

D07784

Dextofisopam:

D03737

Diazepam:

D00293<JP/US>

Estazolam:

D00311<JP/US>

Eszopiclone:

D02624<JP/US>

Ethyl loflazepate:

D01293<JP>

Etizolam:

D01514<JP>

Fludiazepam:

D01354

Flumazenil:

D00697<JP/US>

Flunitrazepam:

D01230<JP>

Flurazepam (DG00919):

D00329 D00695<US> D01408<JP>

Flutazolam:

D01286<JP>

Flutoprazepam:

D01279

Gaboxadol:

D04282

Ganaxolone:

D04300<US>

Glutethimide:

D00532

Halazepam:

D00338

Haloxazolam:

D01758<JP>

Hexobarbital:

D01071

Indiplon:

D02640

Iomazenil:

D02283<JP>

Ketazolam:

D04650

Levotofisopam:

D04721

Loprazolam (DG00921):

D07326 D08145

Lorazepam:

D00365<JP/US>

Lormetazepam:

D01657<JP>

Medazepam (DG00909):

D01292<JP> D04882

Meprobamate:

D00376<US>

Metharbital:

D01382

Methylphenobarbital:

D00700

Mexazolam:

D01316<JP>

Midazolam (DG00920):

D00550<JP/US> D00696<US> D05028

Nimetazepam:

D01593

Nitrazepam:

D00531<JP>

Nordazepam:

D08283

Ocinaplon:

D02617

Oxazepam:

D00464<US>

Oxazolam:

D01278<JP>

Pagoclone:

D02616

Panadiplon:

D05346

Pazinaclone:

D05378

Pentobarbital (DG00915):

D00499 D00500<US> D02253<JP>

Phenobarbital (DG00845):

D00506<JP> D00701<JP/US> D08356

Potassium clorazepate (DG01218):

D00694<JP/US> D03562

Prazepam:

D00470

Propofol (DG00797):

D00549<JP/US> D04257

Quazepam:

D00457<JP/US>

Remimazolam (DG03105):

D10194<JP/US> D11788

Rilmazafone (DG01307):

D01564<JP> D08481

Sarmazenil:

D08507

Secobarbital (DG00917):

D00430 D01310

Suritozole:

D05980

Talbutal:

D06887

Temazepam:

D00370<US>

Thiamylal (DG01377):

D00713<JP> D06106

Thiopental (DG00790):

D00714<JP>

Tofisopam:

D01254<JP>

Topiramate:

D00537<JP/US>

Triazolam:

D00387<JP/US>

Zolpidem (DG00922):

D00706<JP/US> D08690

Zopiclone:

D01372<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2555 (GABRA2)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2555 (GABRA2)
   04723 Retrograde endocannabinoid signaling
    2555 (GABRA2)
  09157 Sensory system
   04742 Taste transduction
    2555 (GABRA2)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2555 (GABRA2)
   05033 Nicotine addiction
    2555 (GABRA2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2555 (GABRA2)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2555 (GABRA2)

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb CytochromB561_N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

4:complement(46243548..46390300)

AA seq 451 aa
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP

NT seq 1356 nt +upstreamnt +downstreamnt
atgaagacaaaattgaacatctacaacatgcagttcctgctttttgttttcttggtgtgg
gaccctgccaggttggtgctggctaacatccaagaagatgaggctaaaaataacattacc
atctttacgagaattcttgacagacttctggatggttacgataatcggcttagaccagga
ctgggagacagtattactgaagtcttcactaacatctacgtgaccagttttggccctgtc
tcagatacagatatggaatatacaattgatgttttctttcgacaaaaatggaaagatgaa
cgtttaaaatttaaaggtcctatgaatatccttcgactaaacaatttaatggctagcaaa
atctggactccagataccttttttcacaatgggaaaaaatcagtagctcataatatgaca
atgccaaataagttgcttcgaattcaggatgatgggactctgctgtataccatgaggctt
acagttcaagctgaatgcccaatgcacttggaggatttcccaatggatgctcattcatgt
cctctgaaatttggcagctatgcatatacaacttcagaggtcacttatatttggacttac
aatgcatctgattcagtacaggttgctcctgatggctctaggttaaatcaatatgacctg
ctgggccaatcaatcggaaaggagacaattaaatccagtacaggtgaatatactgtaatg
acagctcatttccacctgaaaagaaaaattgggtattttgtgattcaaacctatctgcct
tgcatcatgactgtcattctctcccaagtttcattctggcttaacagagaatctgtgcct
gcaagaactgtgtttggagtaacaactgtcctaacaatgacaactctaagcatcagtgct
cggaattctctccccaaagtggcttatgcaactgccatggactggtttattgctgtttgt
tatgcatttgtgttctctgccctaattgaatttgcaactgttaattacttcaccaaaaga
ggatgggcttgggatgggaagagtgtagtaaatgacaagaaaaaagaaaaggcttccgtt
atgatacagaacaacgcttatgcagtggctgttgccaattatgccccgaatctttcaaaa
gatccagttctctccaccatctccaagagtgcaaccacgccagaacccaacaagaagcca
gaaaacaagccagctgaagcaaagaaaactttcaacagtgttagcaaaattgacagaatg
tccagaatagtttttccagttttgtttggtacctttaatttagtttactgggctacatat
ttaaacagagaacctgtattaggggtcagtccttga

DBGET integrated database retrieval system